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The search included articles published between 2010 and 2025, using keywords: Parkinsons disease, -synuclein, dopaminergic degeneration, ferroptosis, deep brain stimulation, stem cell therapy, and AI in PD diagnosis. Results: The review highlights a multifactorial etiology involving -synuclein pathology, oxidative stress, mitochondrial dysfunction, genetic mutations (SNCA, LRRK2, VPS35), environmental toxins, and gut dysbiosis

Secondly, MDSCs can participate in the activation of TAMs, which promote the conversion of M1-TAM to M2-TAM

305 This screen revealed that not only AMPK but also another kinase, HRI, signals mitochondrial distress to mTORC1 (Fig

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[DOI] [PubMed] [Google Scholar] 40.Gruben N., Shiri-Sverdlov R., Koonen D.P.Y., Hofker M.H