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Artificial intelligence for natural product drug discovery

Iron plays the vital role of catalyzing the process of formation of these peroxides, and iron homeostasis is important as a regulatory junction in ferroptosis (Figure 1)

12R-LOX and eLOX-3 are engaged in the synthesis of the cornified envelope (CE) through the enzymatic synthesis of lipid oxide products in the epidermis to maintain the skin barrier and reduce transepidermal water loss (TEWL) (Krieg and Furstenberger, 2014)