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Description

Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta-2 innate immune pathway defective in Crohn disease

The reduction introduces a hydrophilic group in the drug molecule or unmasks the already present hydrophilic group

Pharmaceutical Applications: Research into its application in pharmaceuticals and its potential as a therapeutic agent provides continued opportunities for market expansion

Eur J Med Chem 152:600614 Sozio P, DAurizio E, Iannitelli A, Cataldi A, Zara S, Cantalamessa F, Nasuti C, Di Stefano A (2010) Ibuprofen and lipoic acid diamides as codrugs with neuroprotective activity