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However, excess exposure of a cell to exogenously generated RONS (UV radiation, xenobiotics) or endogenously synthesised RONS (aberrant cell metabolism, inflammation), can overwhelm the cells antioxidant defences, causing an imbalance in redox homeostasis, which gives rise to the condition typically referred to as oxidative stress [42]

All authors read and approved the final manuscript and contributed equally to the manuscript

Padgett, C

10.1016/j.mehy.2015.02.014 7 BattelliM

Fourth, apply single-cell multi-omics to muscle, liver, and adipose to resolve cell-type-specific responses and intercellular signaling

Favaro, E