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UMMC 2014)

Oncogene 33 , 44074417 (2014)

A significant increase in hepatic STAT3 phosphorylation and acetylation and binding of FXR to Stat3 promoter, as well as decreased apoptosis markers by flow cytometry (FAS, caspase 8 and caspase 3), were present in FXR agonist/DDC mice compared to DDC mice

SAMe is the primary methyl donor in the body, while methionine is an essential amino acid that is converted to SAMe in the body

10.1038/379335a0 84 FraternaleD.DufatH.AlbertiniM

To date, five subunits (NR1, NR2a, N2b, N2c, and N2d) of NMDA receptors have been cloned (Moriyoshi et al., 1991, Ikeda et al., 1992, Katsuwada et al., 1992, Meguro et al., 1992, Ishii et al., 1993)