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While IL-6/STAT3 is crucial, compensatory hepatocyte hypertrophy via the PI3K/AKT pathway has been observed in conditional STAT3 KO mice

et al., 2020) (Figure 6c)

& Cho, W.-K

That is still a meaningful step

W., DeSantis, N

This suggests pegylated arginase I will be a suitable candidate for anti-cancer therapy, but more research is required to explore the potential use of pegylated arginase I in treating different cancer types