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In laboratory settings, AOD9604 may be used to investigate pathways related to lipid turnover, cellular energy regulation, and adipose tissue signaling

SAM provides propylamine for the biosynthesis of polyamine and donates a methyl group for the methylation of histone [47]

Over a year of weekly injections, that adds up

Rodent (diet-induced obesity, 11 days) Subcutaneous 5-Amino-1MQ at roughly 34 mg/kg/day reduced body weight and white adipose mass without changing food intake or lean mass

Published in vitro work has characterized 5-Amino-1MQ as a competitive NNMT inhibitor with low micromolar potency against the recombinant enzyme, and as a cell-permeable agent that suppresses NNMT activity in cultured 3T3-L1 adipocytes at micromolar concentrations [1]