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Genes were included in the signature if they satisfied two criteria: 1) if the Average Rank Score (ARS) of the gene was high, that is, the gene was selectively highly expressed in a given cell type compared to all other cell types examined and 2) if the Marker Evaluation Score (MES) of the gene was high, that is, the gene is stably expressed in multiple independent gene expression data sets 22

Soluble fiber can feed the beneficial bacteria in your gut, which can produce short-chain fatty acids (SCFAs) that can improve your intestinal barrier function, lower inflammation, and modulate your immune system

In this experiment we observed similar trends on dehydratase and GST-transferase activity (Extended Data Fig

doi: 10.3389/fphar.2025.1546041 Received 16 December 2024 Accepted 13 May 2025 Published 29 May 2025 Volume 16 - 2025 Edited by Massoud Ranjbar, Bu-Ali Sina University, Iran Reviewed by Yuxiang Fei, China Pharmaceutical University, China Liuqing Yang, Hangzhou Hospital of Traditional Chinese Medicine, China Updates Copyright 2025 Ju, Zhao, Li, Zhang, Xiang and Lian

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Infliximab, azathioprine, or combination therapy for Crohns disease