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Oxidative stress When cells are infected by a virus, there is increased production of free radicals by the mitochondria, peroxisomes, endoplasmic reticulum stress, nicotinamide adenine dinucleotide phosphate hydrogen phosphate (NADPH) oxidase, metabolizing enzymes, and due to the Warburg effect (aerobic glycolysis), causing cells to become stressed and enter apoptosis [296298]

The p62/Keap1/Nrf2/HO-1 pathway is particulary important in regulating susceptibility to ferroptosis by influencing the generation of ROS [65]

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Vocal Cord Nodules and Polyps Vocal cord nodules are benign growths that form on the vocal cords

They also revealed the elevated amounts of cleaved caspase-3 and poly (ADP-ribose) polymerase