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Since recent studies linked HCC in aged mice to the increased accumulation of senescent hepatocytes, we assessed hepatocyte senescence

Sperm cells are particularly vulnerable to oxidative damage because their membranes contain high concentrations of polyunsaturated fats and relatively limited antioxidant defenses

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*Correspondence: Yuhai Wang, [email protected] Xiong, [email protected] These authors have contributed equally to this work This article was submitted to Cellular Neuropathology, a section of the journal Frontiers in Cellular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Transl Psychiatry 13(1):106 Buchanan JL, Rauckhorst AJ, Taylor EB (2023) 3-hydroxykynurenine is a ROS-inducing cytotoxic tryptophan metabolite that disrupts the TCA cycle