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David further analyzed 71 target genes, the prediction of biological processes (BP), including protein phosphorylation (GO:0006468), positive regulation of cell proliferation (GO:0008284), peptidyl-serine phosphorylation (GO:0018105), Positive regulation of gene expression (GO:0010628), negative regulation of apoptotic process (GO:0043066), response to lipopolysaccharide (GO:0032496), positive regulation of MAPK cascade (GO:0043410), positive regulation of MAP kinase activity (GO:0043406) (Figure 11D)

Thorne also sells a stronger version of SynaQuell called SynaQuell+, which increases the doses of most ingredients and adds a few more to go with it

doi: 10.3389/fphar.2022.808855 Received 04 November 2021 Accepted 11 February 2022 Published 17 March 2022 Volume 13 - 2022 Edited by Leo A van Grunsven, Vrije University Brussel, Belgium Reviewed by Prasanna K

Combining the easy scale-up of the DEF-CS single-cell culture system for iPSCs, the highly efficient DE induction by the STEMdiff Definitive Endoderm kit, the robust hepatic specification guided by DMSO and HGF, and the hepatocyte maturation promoted by DEX, dihexa and OSM, this improved method may allow for robust generation of homogeneous functional hepatocytes from human stem cells and opens up new possibilities for drug discovery, hepatotoxicity studies and liver regenerative therapy