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Furthermore, NF-B p65 (P-Ser536), TNF, and IL-1 were measured using commercially accessible kits (NF-B p65 (P-Ser536): cat number: MBS9511033, MyBioSource, San Diego, CA, USA), (TNF: cat number: 438206, Biolegend, San Diego, California, USA), and (IL-1: cat number: E0119Ra, BT LAB, Shanghai, China), respectively

However, PAI-1 carbonylation has been demonstrated to influence its functional activity and structural stability [38], therefore carbonylated PAI-1 may exhibit reduced activity, and we hypothesize that it could trigger a compensatory mechanism leading to an increase in its overall concentration observed in our cohort

R.WallaceM.DivakaruniA

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What this regulatory shift may enable is a more structured environment for clinical research