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However, the increase in mGluRs-dependent signaling in the mouse model of FXS was not confirmed in human-based models, and clinical trials with mGluR inhibitors failed to produce a therapeutic effect in FXS patients [331]

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Hormonal Therapies with Chemotherapy-Like Impact Although not chemotherapeutic in the classical sense, several oral hormonal agents are used as first-line systemic therapies in hormone-sensitive malignancies

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As used herein and unless otherwise indicated, the term "prodrug" means a derivative of a compound that can hydrolyze, oxidize, or otherwise react under biological conditions (in vitro or in vivo) to provide a compound of this invention

[DOI] [PubMed] [Google Scholar] 143.Kumar M., Sandhir R