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Figure 7: Chronic liver disease (steatosis, steatohepatitis, and cirrhosis) is linked to excess inflammatory proteins and fat deposits, which disrupt energy production and metabolism

Tirzepatide slowed the rate of decline in estimated glomerular filtration rate (eGFR) and reduced urinary albumin-to-creatinine ratio (UACR) compared with insulin glargine (UACR remained stable with tirzepatide but increased with insulin glargine), including in participants already receiving an angiotensin-converting enzyme inhibitor, angiotensin receptor blocker or sodium-glucose cotransporter 2 inhibitor (SGLT2i)

JAMA Psychiatry 77 , 12661275 (2020)

[DOI] [PubMed] [Google Scholar] 12.Small D.M., Coombes J.S., Bennett N., Johnson D.W., Gobe G.C

These observations qualified the HepG2 model to study the mechanisms described herein

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