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Front Immunol (2020) 11:924

Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis

The hallmark of NAFLD is hepatic steatosis, but the disease also encompasses non-alcoholic steatohepatitis (NASH) characterized by hepatic inflammation, hepatocyte damage, and fibrosis, highlighting the potentially progressive nature of the disease

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[DOI] [PMC free article] [PubMed] [Google Scholar] 158.Zollner A., Meyer M., Jukic A., Adolph T., Tilg H

Over transferrin bound (TBI) and non-transferrin bound iron (NTBI) can overwhelm the heavy chain ferritin (FtH) capacity, which lead to release of labile iron and render proximal tubular epithelial cells (PTEC) susceptible to iron oxidant damage, especial in distal tubular epithelial cells (DTEC) with lack iron storage (light and heavy chain ferritin) and export protein (ferroportin) (48)