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Ufer, C., Wang, C

The historical context of this research dates back to the 1970s when the therapeutic potential of lithium was first recognized

The anti-inflammatory effects are a consequence of improved mitochondrial efficiency when mitochondria work properly, they produce less ROS, which means less inflammasome activation and less chronic inflammatory signaling

Peer review information Nature Chemical Biology thanks Ali Tavassoli and the other, anonymous reviewer(s) for their contribution to the peer review of this work