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For multiple myeloma, the most common side effects affecting 10% or more patients were: Diarrhea Nausea Low blood counts (low red cells and platelets) Back pain, Swelling in the hands and feet Low calcium levels Upper respiratory tract infection Rash Headache

Statistically, these alterations were different compared to the placebo group

[DOI] [PubMed] [Google Scholar] 6.Wong W.S., Fielding R

In a state of vitamin B 12 deficiency, the cell responds by redirecting folate metabolic pathways to supply increasing amounts of methyltetrahydrofolate