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Although AD animal models hold great promise for elucidating common neural mechanisms, they present significant challenges when investigating NPS, especially in relation to psychosis-related behaviors

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Moreover, experimental manipulations that alter T cell dynamics or MHC II expression in ISCs have demonstrated shifts in epithelial dynamics and cell fate during immune responses, highlighting the dual role of ISCs in tissue regeneration and immune function

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Cells were cultured for 4 days (mean SD, n = 3)