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In the majority of the participants, injection site pain/burning or stinging decreased over time (130 min post-dose), as assessed in a separate yes/no question (data not shown)

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10.1002/adma.202313248 237 SwainS

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Numerous studies on the major alkaloid, mitragynine, and the less abundant constituent, 7-hydroxymitragynine, of kratom have demonstrated the high binding affinity for supraspinal - and -opioid receptors governing the antinociceptive and antitussive actions of these constituents and their rewarding properties (Thongpradichote et al., 1998