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Administration of sedative hypnotics that are substrates of CYP3A4 2 hours after a remdesivir infusion has been recommended to avoid potentially relevant interactions in the case of cotreatment [29]

doi: 10.3390/molecules23071579 103 DamanhouriZAAlkreathyHMAlharbiFAAbualhamailHAhmadMSA

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Furthermore, expression profiling using real-time PCR, western blotting and GSTM2 overexpression following transient knockdown of GSTM1 in HeLa cells confirmed that the absence of GSTM1 activity can be compensated for by the overexpression of GSTM2