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Phospholipase iPLA(2) averts ferroptosis by eliminating a redox lipid death signal

Helps to increase intracellular stores of Glutathione 5

Abstract Konzo is a neglected paralytic neurological disease associated with food (cassava) poisoning that affects the worlds poorest children and women of childbearing ages across regions of sub-Saharan Africa

Improving the supply of raw materials for GSH systems The direct administration of GSH in vivo is probably an obvious way to increase GSH It has been demonstrated that modified oral glutathione-like liposomal GSH increases erythrocyte and plasma GSH levels and reduces oxidative stress biomarkers [98]

Although the time course of Nrf2 stabilization and nuclear translocation indicated a rapid increase with a peak at approximately 6 h for DEM, and a slow but gradual rise triggered by NFT, maximal accumulation of Nrf2 protein, as well as the induction of GCLC and glutathione synthesis, were almost identical for both NFT and DEM after incubation periods of and beyond 24 h (Fig

Grossmann A, Wendel A