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They can be costly, symptomatic if they fail, and in some cases toxic

Pharmacol Res 64:105112 Durgo K, Kosti S, Gradiki K, Komes D, Osmak M, Franeki J (2011) Genotoxic effects of green tea extract on human laryngeal carcinoma cells

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Patients should be aware if they are taking an inhibitor-substrate combination and be mindful of the fact that the two drugs are cooperating synergistically in the body

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