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Table 5 Changes of different acylcarnitine in mental diseases compared with healthy controls

In sensitivity analysis, we also included an isoform of l-carnitine, acetyl-carnitine, proxied by three genetic variants reaching genome-wide significance from the same GWAS as l-carnitine [20]

All three share the core fatty acid transport mechanism but deliver distinct benefits based on molecular structure and tissue distribution

Additionally, because ALCAR increases energy metabolism and cholinergic activity, some sensitive individuals may experience mild overstimulation, restlessness, or insomnia if the dose is too high or taken too late in the day

If you experience digestive problems even at doses of up to 6 g of L-arginine per day, it is best to spread the intake throughout the day (e.g., 2 3 g of L-arginine) and take it with meals to allow for slower absorption