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This results in the downregulation of the activating receptor NKG2D and its ligands, thereby impairing antibody-dependent cell-mediated cytotoxicity (ADCC) and facilitating tumor progression [172, 173]

doi: 10.1074/jbc.M108329200

This process is known as reducing oxidative stress

See JA, Goh CL, Hayashi N, et al

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Melatonin Suppresses Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Signaling and Delays the Development of Hearing Loss in the C57BL/6J Presbycusis Mouse Model