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Contrary to this expectation, recent studies have revealed an unexpected proferroptotic role for complex II

Briefly, mice exhibiting the FUSALS phenotype (characterized by FUS translocation from the nucleus to the cytoplasm) demonstrated longer lifespan, reduced disease severity and improved histological patterns when intracellular HSPA1A was overexpressed (Piavchenko et al., 2024

doi: 10.3390/life12122101 Summary Keywords interstitial lung disease, systemic sclerosis, cyclophosphamide, rituximab, mycophenolate mofetil, tocilizumab, nintedanib, pirfenidone Citation Kamenova A, Tzouvelekis A and Margaritopoulos GA (2023) Recent advances in the treatment of systemic sclerosis associated interstitial lung disease