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Rapid determination of the specificity constant of irreversible inhibitors ( k inact / K I ) by means of an endpoint competition assay

Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages (i.e., higher and/or more frequent doses) and those who have had longer durations of use [see Warnings and Precautions (5.3)]

Published online August 1, 2004 1,831 View 26 Download Abstract PDF BACKGROUND The aim of this study was to evaluate the possible role of NF- B activation and AP-1 by oxidative stress in atherosclerosis in diabetic patients by measuring the carotid intima-media thickness, intracellular ROS generation and activation of transcription factors, including nuclear factor-kappa B (NF- B) and activator protein-1 (AP-1)

From a mechanistic perspective, key takeaways include ( Table 1 ): Table 1 Mitochondrial alterations in immune cells during the perioperative period

10.1016/j.jhep.2005.01.017 33 KimY