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M., Sherman, M

Oral DMTs: An alternative to injectable therapies In 2010, fingolimod (Gilenya , Novartis, Switzerland) was the first oral MS DMT approved by the FDA, with teriflunomide (Aubagio , Genzyme, France) following in 2012 and cladribine (Mavenclad , Merck, Germany) in 2017 approved by the EMA

There are 12 genes involved in the cuproptosis pathway, including seven pro-cuproptosis genes (FDX1, lipoic acid synthetase (LIAS), lipoyltransferase 1 (LIPT1), dihydrolipoamide dehydrogenase (DLD), DLAT, pyruvate dehydrogenase E1 subunit alpha 1 (PDHA1), and pyruvate dehydrogenase E1 subunit beta (PDHB)), three anti-cuproptosis genes (MTF1, glutaminase (GLS), and cyclin-dependent kinase inhibitor 2A (CDKN2A)), and two Cu transporters (ATP7B and SLC31A1) (Liu and Tang, 2022a)