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J., Ruyken, M., van Kessel, K

Glia 32 , 247263 (2000)

Catabolism of BCAAs initiates at the transamination and transfer of nitrogen to -KG by branched-chain amino transferases (BCATs) to produce glutamate and their respective branched-chain -ketoacids (BCKAs) (Figure 1)

Meyer et al., 2002a

Purine metabolism was also significantly enriched, indicating compensatory remodeling of nucleotide pools in response to impaired pyrimidine biosynthesis