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J Contemp Dent Pract 19(2):137142

Increasing TMAO concentrations downregulated APOA4 expression and upregulated PCSK9 expression, demonstrating a concentration-dependent effect of TMAO on both APOA4 and PCSK9 (Supplementary Fig

doi: 10.1016/j.cmet.2021.02.002 111

Taken together with AC/FC reduction by HF treatments in this study, carnitine metabolic changes might be not only distinct prognostic biomarkers, but also be therapeutic targets for HF

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Moreover, the severity of IL-1-induced joint degradation in TLR4 -/- mice was reduced, with similar levels of inflammation, suggesting independent processes (175)