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The release of metalloproteinases, elastase, cathepsin G, and protease 3 by NETs has proteolytic activity, which can disrupt the junctions between endothelial cells (156) and alter the permeability of vascular endothelium

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IDF diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

Bose P, McCue D, Wiederhold NP, Kadia TM, Borthakur G, Ravandi F, Yilmaz M, Takahashi K, Thompson PA, Pemmaraju N, Daver NG, Burger JA, Cortes JE, Garcia-Manero G, Verstovsek S, Konopleva MY, Jain N, DiNardo CD, Alvarado Y, Naqvi K, Kornblau SM , Ferrajoli A, Wierda WG, Estrov ZE, Benton CB, Masarova L, Montalban-Bravo G, Sasaki K, Rausch CR, Marx K, Qiao W, Huang X, Bivins CA, Pierce SA, Kantarjian HM, Kontoyiannis DP