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The findings indicate that the intake of red wine polyphenols could potentially yield advantageous effects on the composition of the intestinal microbiota (68), that is, accelerate the growth of phoenixes, Klebsiella, Bacillus, Bordetella and Staphylococcus , while reducing the growth of Bacteroides , Clostridium , anaerobic coccus, and Bifidobacterium

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Nrf2 counteracts these effects by upregulating SLC7A11, GCLC, and HO-1, enhancing glutathione synthesis and GPX4 activity while inhibiting NF-B (Zhang, 2025