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When young patients present with genital melanosis, the oral mucous membranes should be inspected for the presence of similar pigmentation

This association should be considered in those individuals who are nonobese, lack endocrinopathy, and/or have a recent history of unintentional weight loss

Penile preserving surgery is important, but total glansectomy or total penectomy may occasionally be necessary

PT-141 is soluble in sterile water, saline, or bacteriostatic water

A few considerations a clinician should keep in view: Men with erectile dysfunction who have not responded to PDE5 inhibitors are the most discussed off-label group

Epidemiology Dysplastic nevi are relatively common in the general population.8 Reports have described the prevalence ranging from 2% to 53% in different studies, depending on the diagnostic criteria (clinical or histological).8 A more accurate estimate is considered to be about 2%-8% of Caucasians, with a predilection for young individuals (less than 30 to 40 years of age).18 The frequency of dysplastic nevi in patients with a history of melanoma is much higher: 34% to 59%.18 Evidence suggests that sun exposure, in addition to genetic susceptibility, may increase the appearance of such nevi.1,8,18 Data concerning the prevalence of AMS are difficult to document in part due to the large variability in the diagnostic criteria employed by different studies