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A prototypical example involves LPS activation of Kupffer cells (KCs) through TLR4 signaling, which promotes the secretion of pro-inflammatory mediators such as CC-chemokine ligand 2 (CCL2), interleukin (IL)-8, tumor necrosis factor- (TNF-), IL-1, and IL-6 [35, 39]

After removing the duplicates, they screened the title/abstract and identified a waitlist of potentially relevant studies for further full-text review