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This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

Key Points for Patients It is a chronic condition: Crohns disease cannot currently be cured, but it can be managed effectively with the right treatment

Results depend on your starting point

Researchers seeking access to retatrutide for any clinical context, including individual treatment, should contact Eli Lilly directly or enrol in an authorized clinical trial through the TRIUMPH programs