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Ann Transplant 23 , 110

Crit Rev Plant Sci 38:411430

However, prolonged or excessive UPR activation shifts to pro-apoptotic signals, contributing significantly to -cell apoptosis, loss of -cell mass, and reduced insulin synthesis in both T1DM and T2DM

Secondly, although we measured a series of plasma concentrations of TMAO and its precursors, the measurements were performed only once in the first trimester, making it impossible to assess their dynamic changes throughout the entire pregnancy

As a key regulator in Toll-like receptor (TLR) signaling, ATF2 undergoes p38 MAPK-dependent phosphorylation at Thr71 (107,166), through which it promotes the expression of pro-inflammatory mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), TNF-, IL-6 and IL-1 (167-172)

Psychiatry 193 SurapaneniD