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Certain gut organisms consume bile acids

In the CNS, Prdx2 has been shown to be expressed in neurons and its de-regulation has been associated with several neurodegenerative diseases such as AD and PD [56-59]

HK2 interacts with nuclear proteins such as Max, Sirt1, IWS1, CTR9, and Spin1, increasing chromatin accessibility to regulate gene expression

Recently, a significant correlation was found between specific retinal structural changes and the severity of cognitive impairment in SSD and ASD

While the condition is the major cause of poor vitamin B 12 status in the elderly population, it is usually associated with atrophic gastritis, a chronic inflammation of the lining of the stomach that ultimately results in the loss of glands in the stomach (atrophy) and decreased stomach acid production (see Atrophic gastritis)