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Solasonine also contributed to the ferroptosis of hepatocellular carcinoma cells by the destruction of the glutathione redox system with increasing lipid ROS levels as well as significantly decreasing the levels of GPX4, GSS mRNA, and protein ( TABLE 1 The metabolites from TCM targeting ferroptosis in animal models or cells

METALLURGY C07ORGANIC CHEMISTRY C07DHETEROCYCLIC COMPOUNDS C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links CCHEMISTRY

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