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Nucleic Acids Res 43:W174W181 Perloff MD, Von Moltke LL, Marchand JE, Greenblatt DJ (2001) Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell line

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The and classes of GSTs play a regulatory role in the mitogen-activated protein (MAP) kinase pathway that participates in cellular survival and death signals via protein : protein interactions with c-Jun N-terminal kinase 1 (JNK1) and ASK1 (apoptosis signal-regulating kinase)

doi: 10.1186/s13048-019-0480-x

That pairing isn't arbitrary these two compounds operate on different parts of the same axis and produce a growth hormone pulse that neither can generate alone with the same magnitude or quality