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High melatonin concentrations in third ventricular cerebrospinal fluid are not due to Galen vein blood recirculating through the choroid plexus

also demonstrated that in TNBC cells, the SOX2-ABCG2-TWIST1 pathway plays a significant role in regulating tumorigenicity and chemoresistance [195]

Their advantageous properties, including low molecular weight, minimal immunogenicity, facile chemical synthesis, robust tissue penetration, and an expansive target scope, position them as compelling alternatives to antibodies for addressing the cardinal limitations of PROTACs, namely poor selectivity, off-target toxicity, and inadequate delivery efficiency (Fig

Nutlin-3, an inhibitor of murine double minute 2 (MDM2), enhances p53 stability and preserves intracellular GSH levels via a p53-dependent mechanism, allowing cell survival under cystine-deprived conditions (98)

The presence of an electrophilic hydroxyl group on the chroman ring, allows Vitamin E to be a strong antioxidant

MtDNA copy number quantification MtDNA was quantified using qPCR as described 83