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Single colonies were isolated and identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) using a Biotyper System (Bruker Daltonics Inc.) (64)

Over time, however, the LA loses its contractile function, leading to mechanical failure and structural changes (146)

To unravel the metabolic modifications associated with the onset of obesity and diabetes, we conducted metabolomic and transcriptomic analyses on WT and Alms1 -/- mice at three distinct ages: at 6 weeks of age (before the development of AS symptoms), at 10 weeks of age (when Alms1 -/- mice have acquired initial signs of an AS-like phenotype, including obesity), and at 20 weeks of age (when Alms1 -/- mice have developed an advanced AS-like phenotype) (Fig

10.1196/annals.1432.043 151 GorantlaS.LiuJ.SnellerH.DouH.HolguinA.SmithL.et al

Non alcoholic fatty liver disease and metabolic syndrome

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