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Metabolic abnormalities such as the Warburg effect, which is characterized by excessive glucose uptake and lactate generation, are frequently seen in cancer cells (Hu et al., 2022)

These results demonstrate that TGF--induced transition from fibroblasts to myofibroblasts involves canonical TGF-/Smad2/3 signaling, non-canonical TGF-/ERK1/2 signaling, and ROS production via NAD(P)H oxidase

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Another study pointed out that pretreatment with 100 mg/kg NAC eliminated paclitaxel-induced allodynia in the CIPN mouse model, while in RAW264.7 cells, 50 mM NAC completely blocked the paclitaxel-induced release of high mobility group box 1 (HMGB1) and upregulation of CREB-binding protein (CBP) and p300/CBP-associated factor (PCAF) [63]

While there is no evidence of common structural or functional brain alterations in PAIS, probably due to its heterogeneous origin and lack of conceptualization, ME/CFS has been extensively studied with MRI (magnetic resonance imaging), as recently reviewed by Nelson et al

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