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CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1

o S en una posicin que corresponde a la posicin 196 E en una posicin que corresponde a la posicin 420 y E en una posicin que corresponde a la posicin 424, con referencia a las posiciones de aminocidos que se muestran en la SEQ ID For example, between the modified FX polypeptides or the isolated modified FX polypeptides described herein, including any described above, are the FX polypeptides that contain an (s) substitution (s) of amino acid (s): S in a position corresponding to position 196, S in a position corresponding to position 211 and H in a position corresponding to position 219

Emsley P, Lohkamp B, Scott WG, Cowtan K

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In particular examples, the modified FXa polypeptides are FX polypeptides that contain a light chain having the sequence of amino acids 1-139 shown in ID n : 134 (ie, corresponding to amino acids 1-139 of any of the SEQ ID NOS: 136-265), or a light chain having an amino acid sequence that is at least 75%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91% , 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more sequence identity with amino acids 1-139 shown in any of SEQ ID NOS: 134

doi: 10.1007/s40120-024-00642-5 6