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Cell Death Dis 15 , 534 (2024)

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Therapeutic targeting of proteostasis in NDDs NDDs are unified by the progressive accumulation of misfolded and aggregation-prone proteins, chronic cellular stress, and selective neuronal vulnerability

However, the BBB likewise precludes the transit of most drugs into the brain, making it difficult for chemotherapeutic agents to reach therapeutically effective concentrations in brain tissue

Studies that specifically examined the combined effects of HBOT and NAC as therapeutic modalities in animal models are summarized in Table 1 ( TABLE 1 Effects of combined HBOT and NAC administration in different experimental animal models