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3A,B, compare lanes 3 and 1), in agreement with previous studies (Nishiyama et al, 2010)
Cualquier modificacin proporcionada en el presente documento se puede combinar con cualquier otra modificacin conocida por un experto en la materia (por ejemplo, cualquiera que se muestre en la Seccin D.5) siempre que el polipptido de FX modificado resultante presente un aumento en la dependencia del cofactor, un aumento de la resistencia a los inhibidores, glicosilacin alterada (por ejemplo, hiperglicosilacin) y/o semivida aumentada y preserve la actividad de coagulacin dependiente de FVa en comparacin con el polipptido de FX que no contiene las modificaciones cuando cada una est en su forma activa bicatenaria.Any modification provided herein may be combined with any other modification known to one skilled in the art (e.g., any shown in Section D.5) provided that the resulting modified FX polypeptide exhibits an increase in dependence
4-HNE can form covalent bonds with proteins, DNA, and phospholipids, thereby disrupting cellular functions and playing a role in the pathogenesis of various diseases [144]
Q ID NO: 134), the western white-cheeked gibbon (precursor prepropeptide shown in SEQ ID NOS: 393 and the mature form shown in SEQ ID NO: 404), the olive green baboon (precursor precursor which shown in SEQ ID NO: 394 and the mature form of SEQ ID NO: 405), the macaque (precursor prepropeptide shown in SEQ ID NO: 395 and the mature form shown in SEQ ID NO: 406), the dark marmoset (precursor prepropeptide shown in SEQ ID NO: 396 and the mature form shown in SEQ ID NO: 407), the African elephant (precursor prepropeptide shown in SEQ ID NO
Carriage of the SOD2 C47T (rs4880) polymorphism has been associated with steatosis as well as more advanced fibrosis in MASH (Al-Serri et al
