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SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress

The influences of various scavengers on the oxidase-like activity of pFeSAN were investigated by comparing the activity in the absence or presence of ROS scavengers

10.1161/CIRCRESAHA.114.303204 249

In hepatocytes, oxalate overload caused mitochondrial dysfunction and lipid accumulation by inhibiting the transcription of peroxisome proliferator-activated receptor and blocking mitochondrial FAO

Studies also suggest that it may eventually be developed into an orally available and safe therapeutic agent for obesity, making it a convenient option for patients [2]

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