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In the alternate pathway, activity of the C27 hydroxylase is preceded by that of 12 hydroxylase (CYP8B1), which adds a third hydroxyl group to the steroid nucleus, ultimately yielding the tri-hydroxy bile acid, cholic acid

Nat Med 32 , 883893 (2026)

Acetaminophen (APAP) metabolic pathway

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Of these individuals, up to 15% of have NASH

In contrast to their protein-bound counterpart, FAAs can interact with specific receptors present on a wide variety of cells in various parts of the body, including the intestines, where they can activate specific intracellular pathways and confer physiological effects (48)