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Osteocyte: Derived from osteoblasts, located within the bone matrix, responsible for sensing bone stress, regulating bone metabolism, and maintaining calcium and phosphorus balance

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In addition, impaired production of TGF- by phagocytes (185,200) reduces collagen production by healthy smooth muscle cells (Figures 4 and 5)

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Overall, the systemic ORR was 45.3% in patients with BrM and 32.6% in patients without BrM (122)