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In addition, short-term use is poorly defined, and little is known about the safety of long-term use or high dosages ( Moreover, due to its high cost, some products claiming to contain goldenseal may not contain any amount of this plant or very little of it

Anti-neural antibody reactivity is higher in those with persistent symptoms, even among those who are seronegative, compared to those who returned to health after treatment for Lyme disease (149)