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Abnormal trajectory: expanding redness beyond 3cm diameter, increasing warmth, new onset of pain after initial comfort, or lymphatic streaking (red lines extending from the site toward the trunk)

Lubis, A

Blood 140:152156 Zerbit J, Detroit M, Meyer A, Decroocq J, Deau-Fischer B, Deschamps P, Birsen R, Mondesir J, Franchi P, Miekoutima E (2022) Patients with hematological malignancies treated with T-cell or B-cell immunotherapy remain at high risk of severe forms of COVID-19 in the omicron era

Patients at low-risk for fracture should be considered for drug discontinuation after 3 to 5 years of use

CIRS is marked by persistent innate immune activation, often triggered by biotoxin exposure (e.g., mold, cyanobacteria, Lyme-associated microbes) in genetically susceptible individuals

Once the microglia engulf the senescent neurons, they become senescent, dysfunctional and amplify pathogenesis through inflammation, releasing toxic tau and failure to survey the brain microenvironment