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The mechanistic interpretation offered most often is straightforward: recruiting the GIP pathway alongside GLP-1 appears to add to the metabolic effect rather than substitute for it

Across those trials the compound's tolerability was reported as comparable to placebo, with no statistically significant effects detected on serum IGF-1, fasting glucose, insulin, HbA1c, cortisol, or thyroid hormones at the levels studied, and no serious adverse events attributed to the compound [7]

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In some cases, patients may experience residual pain relief for up to eight hours